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SAMERAL 400

Ademetionine 400 mg Tablets

For Liver Health, Detoxification & Mood Support


SAMERAL 400 is a premium formulation of Ademetionine (SAMe) — a vital compound naturally found in the body, known to support liver detoxification, cellular repair, and mood regulation.

 

It plays a key role in methylation reactions, antioxidant defense, and neurotransmitter balance.

 Indications of SAMERAL-400

SAMERAL 400 is used in the management of:

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  • Intrahepatic Cholestasis (Pregnancy/Chronic Liver Disease)

  • Alcoholic Liver Disease

  • NAFLD / MASLD

  • Drug-Induced Hepatotoxicity

  • Liver Cirrhosis & Fibrosis

  • Depression in liver-compromised patients

  • Adjunct in Parkinson’s Disease & Fibromyalgia (off-label)

Mechanism of Action

  • Donates methyl groups for >100 metabolic processes

  • Boosts glutathione production for liver detox

  • Enhances liver regeneration and reduces oxidative stress

  • Modulates neurotransmitters (serotonin, dopamine)

  • Supports membrane repair and improves hepatocyte function

Clinical Benefits

  • Improves liver enzyme levels and hepatocellular function

  • Reduces cholestasis and supports bile flow

  • Enhances mood and neurological function in liver patients

  • May slow the progression of liver fibrosis

  • Well tolerated with minimal side effects

Dosage and Administration

  • Standard dose: 400–800 mg/day in divided doses

  • Take on an empty stomach

  • Swallow whole; do not crush or chew

  • Follow the physician’s dosage recommendations

Corrects Impaired SAMe Cycle via 3 Unique Pathways:

A Complete Support in Hepatic Restoration

WHO-GMP compliant formulation

Trusted by liver specialists

Dual benefit- Hepatic & Neurological

Also Available

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Safety, Tolerability & Precautions

  • Generally well tolerated

  • Mild effects: Nausea, insomnia, headache

  • Rare: Anxiety or mild mania (especially in high doses or bipolar disorder)

  • Contraindicated in:

  • Hypersensitivity to SAMe

  • Severe bipolar disorder

  • Use cautiously during pregnancy, lactation, or with SSRIs/MAO inhibitors.

Packaging & Storage

  • Form: Enteric-coated tablet

  • Pack Size: 10x1x10 blister

  • Storage: Below 25°C, protected from light & moisture

  • Keep out of reach of children

Scientific Evidence

RCTs and meta-analyses support use in:

  • Chronic liver diseases (improved histology & transaminase levels)

  • Cholestasis (reduced bile acids)

  • Depression (efficacy similar to tricyclic antidepressants with fewer side effects)

  • Backed by AASLD, EASL, and ESHG recommendations as an adjuvant liver therapy.

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